However, benign lesions and healthy tissue did not significantly differ in diffusion characteristics. The three-component model discriminated malignant from benign and healthy tissue, particularly using the restricted diffusion C 1 compartment and product of the restricted and intermediate diffusion compartments ( C 1 and C 2). The signal contributions from three distinct diffusion compartments were measured to generate parametric maps corresponding to diffusivity on a voxel-wise basis. We further evaluated the utility of this three-component model to differentiate malignant from benign lesions and healthy tissue in 12 patients with known malignancy and synchronous pathology-proven benign lesions. Previously, a three-component restriction spectrum imaging (RSI) model demonstrated the ability to distinguish malignant lesions from healthy breast tissue. Multi-component modeling of the DW-MRI signal over an extended b-value range (up to 3000 s/mm 2) theoretically isolates the slowly diffusing (restricted) water component in tissues. Diffusion-weighted MRI (DW-MRI) offers a potential adjunct to dynamic contrast-enhanced MRI to discriminate benign from malignant breast lesions by yielding quantitative information about tissue microstructure.
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